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个人简介

胡连哲,男,1986年出生于河南新乡,副教授,分析化学博士,硕士生导师,重庆市巴渝学者青年学者。

E-mail: lianzhehu@cqnu.edu.cn  

学习及工作经历:

2007.9-2013.1 中国科学院长春应用化学研究所 硕博连读 获分析化学博士学位

导师: 徐国宝研究员(中科院百人计划,电分析化学国家重点实验室副主任)

2003.9-2007.7 吉林大学手机版沙巴体育平台 本科

2016.12-至今 重庆师范大学 手机版沙巴体育平台 副教授 硕士生导师 (2018年3月-2018年9月在重庆市科技局科技人才与基础研究处挂职)

2015.12-2016.12 重庆师范大学 手机版沙巴体育平台 讲师(以校特聘教授待遇引进)

2015.4-2015.11 南洋理工大学(新加坡)博士后

合作导师:Prof. Fangwei Shao      

2014.3-2015.3 耶路撒冷希伯来大学 (以色列)博士后

合作导师:Prof. Itamar Willner      

2013.2-2014.2 阿卜杜拉国王科技大学 (沙特阿拉伯) 博士后

合作导师:Prof. Niveen Khashab      

研究方向与成果简介:

胡连哲老师在纳米探针、仿酶催化、发光材料、DNA纳米技术等领域具有多年的研究经验。目前,课题组的研究方向主要聚焦于纳米酶的制备及生物分析应用,主要包括2个方面:(i)开发新型的纳米酶材料,研究纳米材料的仿酶催化性能,探索纳米酶在生物医药、生命起源、工业催化中的可能应用;(ii)发展基于纳米酶材料的分析方法,如基于纳米酶的酶联免疫分析试剂盒、便携式试纸条、光学检测及成像分析方法等。

胡连哲老师已经在国际高水平学术期刊上发表SCI论文50余篇,包括Chem. Soc. Rev. (IF=54.564), Nano Lett. (IF=11.189), Biosens. Bioelectron. (IF=10.257), Anal. Chem. (IF=6.785), Chem. Commun. (IF=5.996)等。论文SCI他引达2000余次,单篇引用最高达588次,其中3篇论文入选ESI高被引论文(化学学科前1%)。担任Chem. Commun., Anal. Chem., ACS Appl. Mater. Interfaces等国际学术期刊同行评议审稿人。曾获得中国科学院研究生院-澳大利亚必和必拓奖学金、中国科学院研究生院优秀毕业生、重庆师范大学青年拔尖人才、重庆市巴渝学者青年学者等荣誉奖励。主持国家自然科学基金1项、重庆市留学人员回国创业创新支持计划创新类优秀项目1项、重庆市科技局面上项目1项、重庆市教委科技项目2项、重庆师范大学青年拔尖人才项目1项、重庆师范大学人才引进项目1项。

主讲课程:《仪器分析》,《仪器分析实验》,《专业英语》等。

代表性论文:

1.Ting Huang, Xilu Hu, Min Wang*, Yuxin Wu, Lianzhe Hu* and Zhining Xia*, Ionic liquid-assisted chemiluminescent immunoassay of prostate specific antigen using nanoceria as an alkaline phosphatase-like nanozyme label,Chemical Communications, 2021, 57, 3054.(IF: 5.996)      

2.Lianzhe Hu*,Xilu Hu, Ting Huang, Min Wang* and Guobao Xu*,Chemiluminescence of the Ce(IV)/CDP-Star System Based on the Phosphatase-like Activity of Ce(IV) Ions,ACS Omega,2021,6,6379-6384.(IF: 2.870)      

3.Xilu Hu, Ting Huang, Hong Liao, Lianzhe Hu* and Min Wang*,The phosphatase-like activity of zirconium oxide nanoparticles and their application in near-infrared intracellular imaging,Journal of Materials Chemistry B, 2020,8, 4428-4433.(IF: 5.344)      

4.Xue Tian, Hong Liao, Min Wang, Lingyan Feng, Wensheng Fu, Lianzhe Hu*, Highly sensitive chemiluminescent sensing of intracellular Al3+ based on the phosphatase mimetic activity of cerium oxide nanoparticles, Biosensors and Bioelectronics, 2020,152, 112027.(IF: 10.257)      

5.Hong Liao, Ting Huang, Lianzhe Hu*, Min Wang*, Fluorescent aptasensors for parallel analysis of biomolecules based on interlocked DNA catenane nanomachines, Analytica Chimica Acta, 2020,1114,1-6. (IF: 5.977)        

6.Hong Liao, Yilin Liu, Min Chen, Min Wang, Hua Yuan, Lianzhe Hu*, A colorimetric heparin assay based on the inhibition of the oxidase mimicking activity of cerium oxide nanoparticles, Microchimica Acta, 2019, 186, 274.(IF: 6.232)      

7.Lianzhe Hu*, Qian Zhang, Xiaoyan Gan, Weiling Yin, Wensheng Fu, Switchable fluorescence of MoS2 quantum dots: a multifunctional probe for sensing of chromium(VI), ascorbic acid, and alkaline phosphatase activity, Analytical and Bioanalytical Chemistry,2018, 410, 7551-7557.(IF: 3.637)      

8. Min Wang*, Christian Wiraja, Meiling Wee, David Yeo, Lianzhe Hu*,Chenjie Xu*, Hairpin-structured probe conjugated nano-graphene oxide for the cellular detection of connective tissue growth factor mRNA, Analytica Chimica Acta,2018, 140-147.(IF: 5.977)      

9.Lianzhe Hu*,Qian Zhang, Xiaoyan Gan, Sili Lin, Shuang Han, Zhichao Zhang, Fluorometric turn-on determination of the activity of alkaline phosphatase by using WS2 quantum dots and enzymatic cleavage of ascorbic acid 2-phosphate, Microchimica Acta, 2018, 185, 390.(IF: 6.232)      

10.Lianzhe Hu*,Hong Liao, Lingyan Feng, Min Wang and Wensheng Fu*.Accelerating the Peroxidase-Like Activity of Gold Nanoclusters at Neutral pH for Colorimetric Detection of Heparin and Heparinase Activity,Analytical Chemistry,2018,90, 6247-6252.(IF: 6.785)      

11. Hong Liao, Lianzhe Hu*,Yuzhen Zhang, Xianrong Yu,Yilin Liu, Rong Li,A highly selective colorimetric sulfide assay based on the inhibition of the peroxidase-like activity of copper nanoclusters,Microchimica Acta,2018, 185, 143.(IF: 6.232)      

12. Hong Liao,Guangjuan Liu, Yun Liu,Rong Li,Wensheng Fu and Lianzhe Hu*,Aggregation-induced accelerating peroxidase-like activity of gold nanoclusters and their applications for colorimetric Pb2+detection,Chemical Communications,2017,53, 10160-10163.(IF: 5.996)

工作之前部分代表性论文:

1. Lianzhe Hu, Chun-Hua Lu, Itamar Willner*, Nano Lett. 2015, 15, 2099-2103.(影响因子:11.189

2. Lianzhe Hu, Xiaoqing Liu, Alessandro Cecconello, Itamar Willner*, Nano Lett. 2014, 14, 6030-6035.(影响因子:11.189

3. Lianzhe Hu, Lin Deng, Shahad Alsaiari, Dingyuan Zhang, Niveen M. Khashab*, Anal. Chem. 2014, 86, 4989-4994.(影响因子:6.785

4. Lianzhe Hu, Shuang Han, Saima Parveen, Yali Yuan, Ling Zhang, Guobao Xu*,Biosens. Bioelectron. 2012, 32, 297-299.(影响因子:10.257

5. Lianzhe Hu, Guobao Xu*, Chem. Soc. Rev. 2010, 39, 3275-3304.(影响因子:54.564

6. Lianzhe Hu,Zheng Bian,Haijuan Li, Shuang Han, Yali Yuan,Lianxun Gao, Guobao Xu*, Anal. Chem. 2009, 81, 9807-9811.(影响因子:6.785

7. Lianzhe Hu, Haijuan Li, Shuyun Zhu,Lishuang Fan, Lihong Shi, Xiaoqing Liu, GuobaoXu*,Chem. Commun.2007, 4146-4148.(影响因子:5.996

申请及授权专利:

1. 胡连哲,刘光娟,刘蕴,付文升,石墨烯量子点的用途及试剂盒,发明专利,专利号:ZL 2017 1 0342987.9.      

2. 胡连哲,张玉珍,余先容,金纳米簇与铜锌超氧化物歧化酶的用途及试剂盒,发明专利,专利号:ZL 2017 1 0342988.3.      

3. 胡连哲,胡喜露,廖红,二氧化锆纳米粒子作为碱性磷酸酶纳米模拟物的应用,发明专利,申请号:202010043105.0.